The Role of Advanced Glycation End Products in Diabetic Vascular Complications
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products (AGEs) and diabetic vascular complications.
Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and macroangiopathy. Among various metabolic derang...
متن کاملAdvanced Glycation End Products and Diabetic Complications
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other di...
متن کاملAdvanced glycation end products and diabetic complications: a general overview.
Diabetes mellitus, especially type 2 diabetes is increasing at an alarming rate reaching epidemic proportions. Although hyperglycemia has been considered as playing an important role in the pathogenesis of diabetic complications, the mechanisms involved remain uncertain. There are several theories as to how chronic hyperglycemia can lead to micro or macrovascular disease in diabetes, including ...
متن کاملAdvanced glycation end-products and the progress of diabetic vascular complications.
Epidemiological studies have confirmed that hyperglycemia is the most important factor in the onset and progress of vascular complications, both in Type 1 and 2 diabetes mellitus. The formation of advanced glycation end-products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that accelerated chemical modification of proteins by glucose during hyperglycemia contributes to t...
متن کاملAdvAnced GlycAtion end Products (AGes): it’s role in the PAthoGenesis of diAbetic comPlicAtions
Initially, aldehyde of glucose molecule produces a labile covalent bond with the amino acid side chain (specifically lysine residues in protein) of both sugar and lipids. This initial glycation reaction is reversible & leads to development of fructose – lysine residues, a Schiff base. This Schiff base, in tern, undergoes molecular re-arrangement to form one ketoamine known as Amadori product.2 ...
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ژورنال
عنوان ژورنال: Diabetes & Metabolism Journal
سال: 2018
ISSN: 2233-6079,2233-6087
DOI: 10.4093/dmj.2017.0105